Endocrine Abstracts

Propionate upregulates leptin synthesis through the G protein-coupled receptor 41 (GPR41) in mice. In contrast to monogastric mammals, ruminants almost entirely depend on short chain fatty acids as energy source, but the reports about the physiological relevance of propionate for leptin secretion in these species are controversial and the importance of the GPR41 for its regulation is not yet clarified. Here we characterise the effects of intravenously infused propionate on the...